11GH
Structure of GMPPNP-bound KRAS-G12C/Y96D, a Switch-II Pocket Inhibitor Resistance Mutant, in Complex with the RAF1 RBD-CRD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GTPase KRas | polymer | 170 | 19310.8 | 1 | UniProt (P01116) | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | B (B) | RAF proto-oncogene serine/threonine-protein kinase | polymer | 138 | 15945.5 | 1 | UniProt (P04049) | Homo sapiens (human) | Proto-oncogene c-RAF,cRaf,Raf-1 |
| 3 | C (A) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 5 | E, F (B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) PubChem (32051) | |||
| 6 | G, H (A, B) | water | water | 18.0 | 70 | Chemie (HOH) |
Sequence modifications
A: 1 - 169 (UniProt: P01116)
B: 52 - 188 (UniProt: P04049)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Cys 12 | Gly 12 | engineered mutation |
| Asp 96 | Tyr 96 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 51 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35256.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 677.3 | |
| All* | Total formula weight | 35933.6 |
