11FU

Structure of GDP-bound KRAS-G12C/R68S, a Switch-II Pocket Inhibitor Resistance Mutant

Summary for 11FU

• Entry DOI: 10.2210/pdb11fu/pdb
• Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: ras, oncogenic mutation, drug resistance, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 59341.60

Authors

Whitley, M.J.,Simanshu, D.K. (deposition date: 2026-02-21, release date: 2026-10-07)

• Primary citation: Whitley, M.J.,Dyba, M.,Chakrabarti, M.,Smith, B.P.,Chan, A.H.,Denson, J.P.,Messing, S.A.,Lin, K.,Cornilescu, G.,Balius, T.E.,Nissley, D.V.,McCormick, F.,Maciag, A.E.,Simanshu, D.K.; Structural mechanisms underlying resistance to Switch-II pocket inhibitors in KRAS; Nat Commun, 2026; DOI: 10.1038/s41467-026-78133-4

Experimental method

X-RAY DIFFRACTION (1.65 Å)