11FU
Structure of GDP-bound KRAS-G12C/R68S, a Switch-II Pocket Inhibitor Resistance Mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | GTPase KRas | polymer | 170 | 19288.7 | 3 | UniProt (P01116) | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | D, G, J (A, B, C) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 3 | Chemie (GDP) | |||
| 3 | E, F, H, I, K... (A, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) PubChem (888) | |||
| 4 | M, N, O (A, B, C) | water | water | 18.0 | 335 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Cys 12 | Gly 12 | engineered mutation |
| Ser 68 | Arg 68 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 57866.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1475.4 | |
| All* | Total formula weight | 59341.6 |
