11CF

CHAP domain of Staphylococcus aureus-specific lysin L1

Summary for 11CF

Entry DOI	10.2210/pdb11cf/pdb
Descriptor	Probable cell wall hydrolase LytN, SODIUM ION, GLYCEROL, ... (4 entities in total)
Functional Keywords	lysin, chap, enzyme, peptidoglycan, bacteria, phage, lysm, endopeptidase, hydrolase
Biological source	Staphylococcus aureus
Total number of polymer chains	4
Total formula weight	66772.07
Authors	Miller, H.A.,Palowitch, G.M.,Dulberger, C.L. (deposition date: 2026-02-17, release date: 2026-05-06)
Primary citation	Badarau, A.,Bauer, B.,Visram, Z.,Qiao, R.,Majoros-Hashempour, A.,Sollner, J.,Durica-Mitic, S.,Dunne, O.M.,Kluj, R.,Kestemont, D.,Kieninger, A.K.,Kulig, M.,Berdaguer, R.,Schwebs, T.,Zerbs, M.,Czermak, P.,von Freyberg, M.,Schmidt, J.,Schmidberger, L.,Mayer, D.,Protano, M.,Miller, H.A.,Palowitch, G.M.,Dulberger, C.L.,Massaro, M.,Ivanisenko, N.,Jacomet, H.,Ngatcha Bakoue, D.,Oteri, F.,Sela, G.,Corsini, L. Multi-dimensional optimization of a lysin towards a ribolysin against life-threatening S. aureus infections: Fc-LysM-CHAP and its strong synergy with standard of care antibiotics Biorxiv, 2026 Cited by DOI: 10.64898/2026.04.27.720530 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation