10GH

Cryo-EM structure of Receptor Tyrosine Kinase ROS1 in complex with Fab-RX5

Summary for 10GH

• Entry DOI: 10.2210/pdb10gh/pdb
• EMDB information: 45172 75151
• Descriptor: Proto-oncogene tyrosine-protein kinase ROS, Fab-RX5 light chain, Fab-RX5 heavy chain, ... (5 entities in total)
• Functional Keywords: receptor tyrosine kinase, ros1 extracellular bent-over conformation, inhibitory fab-rx5, transferase-immune system complex, transferase/immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 3
• Total formula weight: 165516.07

Authors

Li, H.,Klein, D. (deposition date: 2026-01-19, release date: 2026-02-25)

• Primary citation: Li, H.,Klein, D.; Clustering and a conformational switch drive activation of the mammalian receptor tyrosine kinase ROS1; To Be Published, ; DOI: 10.1038/s41467-026-69630-7

Experimental method

ELECTRON MICROSCOPY (3.06 Å)