10FT

Cryo-EM structure of receptor tyrosine kinase ROS1 in complex with NELL2

Summary for 10FT

• Entry DOI: 10.2210/pdb10ft/pdb
• EMDB information: 75142
• Descriptor: Protein kinase C-binding protein NELL2, Proto-oncogene tyrosine-protein kinase ROS, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: receptor tyrosine kinase ros1, ros1-nell2 complex, transferase-signaling protein complex, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 205579.45

Authors

Li, H.,Klein, D. (deposition date: 2026-01-17, release date: 2026-02-25)

• Primary citation: Li, H.,Klein, D.; Clustering and a conformational switch drive activation of the mammalian receptor tyrosine kinase ROS1; To Be Published, ; DOI: 10.1038/s41467-026-69630-7

Experimental method

ELECTRON MICROSCOPY (3.21 Å)