10FT

Cryo-EM structure of receptor tyrosine kinase ROS1 in complex with NELL2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Protein kinase C-binding protein NELL2	polymer	817	91568.3	1	UniProt (Q99435)	Homo sapiens (human)	NEL-like protein 2,Nel-related protein 2
2	B (A)	Proto-oncogene tyrosine-protein kinase ROS	polymer	1011	113126.4	1	UniProt (Q78DX7)	Mus musculus (house mouse)	Proto-oncogene c-Ros,Proto-oncogene c-Ros-1,Receptor tyrosine kinase c-ros oncogene 1,c-Ros receptor tyrosine kinase
3	C, D, E, F (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)

Sequence modifications

B: 22 - 816 (UniProt: Q99435)

PDB	External Database	Details
Gly 817	-	expression tag
Gly 818	-	expression tag
Gly 819	-	expression tag
Gly 820	-	expression tag
Ser 821	-	expression tag
Ile 822	-	expression tag
Glu 823	-	expression tag
Gly 824	-	expression tag
Arg 825	-	expression tag
Ser 826	-	expression tag
Leu 827	-	expression tag
Asp 828	-	expression tag
His 829	-	expression tag
His 830	-	expression tag
His 831	-	expression tag
His 832	-	expression tag
His 833	-	expression tag
His 834	-	expression tag
His 835	-	expression tag
His 836	-	expression tag
His 837	-	expression tag
His 838	-	expression tag

A: 27 - 1034 (UniProt: Q78DX7)

PDB	External Database	Details
Ser 24	-	expression tag
Leu 25	-	expression tag
Asp 26	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	204694.6
Non-Polymers*	Number of molecules	4
	Total formula weight	884.8
All*	Total formula weight	205579.5

*Water molecules are not included.