10DJ

Fyn Kinase Domain-Saracatinib Complex Structure

Summary for 10DJ

• Entry DOI: 10.2210/pdb10dj/pdb
• Descriptor: Tyrosine-protein kinase Fyn, N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE (3 entities in total)
• Functional Keywords: tyrosine-protein kinase fyn, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 65830.44

Authors

Ta, H.M.,MacKenzie, K.,Ferreon, J.C.,Ferreon, A.C.,Kim, C. (deposition date: 2026-01-13, release date: 2026-03-18)

• Primary citation: Ta, H.M.,Sankaran, B.,Roush, E.D.,Ferreon, J.C.,Ferreon, A.C.M.,Kim, C.; Fyn-Saracatinib Complex Structure Reveals an Active State-like Conformation; Int J Mol Sci, 27:1143-, 2026; DOI: 10.3390/ijms27031143

Experimental method

X-RAY DIFFRACTION (2.22 Å)