10DJ
Fyn Kinase Domain-Saracatinib Complex Structure
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase Fyn | polymer | 282 | 32373.2 | 2 | UniProt (P06241) | Homo sapiens (human) | Proto-oncogene Syn,Proto-oncogene c-Fyn,Src-like kinase,SLK,p59-Fyn |
| 2 | C, D (A, B) | N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE | non-polymer | 542.0 | 2 | Chemie (H8H) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 458 | Chemie (HOH) |
Sequence modifications
A, B: 263 - 537 (UniProt: P06241)
| PDB | External Database | Details |
|---|---|---|
| Val 538 | - | expression tag |
| Asp 539 | - | expression tag |
| Glu 540 | - | expression tag |
| Asn 541 | - | expression tag |
| Leu 542 | - | expression tag |
| Tyr 543 | - | expression tag |
| Phe 544 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64746.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1084.1 | |
| All* | Total formula weight | 65830.4 |
