9ZWW
Crystal structure of the N4BP2 polynucleotide kinase domain complexed with ATP, Mg, and the trinucleotide substrate CCA.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | NEDD4-binding protein 2 | polymer | 182 | 21288.3 | 3 | UniProt (Q86UW6) Pfam (PF13671) | Homo sapiens (human) | N4BP2,BCL-3-binding protein |
| 2 | D, E, F (D, E, F) | 5'-OH RNA (5'-r(CpCpA)-3') | polymer | 3 | 894.6 | 3 | synthetic construct | ||
| 3 | G, J, N (A, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) PubChem (888) | |||
| 4 | H, K, O (A, B, C) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 3 | Chemie (ATP) | |||
| 5 | I, L, Q, R (A, B, C) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 6 | M, S (B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 7 | P (C) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 1 | Chemie (IPA) PubChem (3776) | |||
| 8 | T, U, V, W, X... (A, B, C, D, E...) | water | water | 18.0 | 552 | Chemie (HOH) |
Sequence modifications
A, B, C: 428 - 595 (UniProt: Q86UW6)
| PDB | External Database | Details |
|---|---|---|
| Gly 414 | - | expression tag |
| Ser 415 | - | expression tag |
| His 416 | - | expression tag |
| Met 417 | - | expression tag |
| Ala 418 | - | expression tag |
| Thr 419 | - | expression tag |
| Asp 420 | - | expression tag |
| Tyr 421 | - | expression tag |
| Lys 422 | - | expression tag |
| Asp 423 | - | expression tag |
| Asp 424 | - | expression tag |
| Asp 425 | - | expression tag |
| Asp 426 | - | expression tag |
| Lys 427 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 66548.9 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 2162.9 | |
| All* | Total formula weight | 68711.8 |
