9ZUZ

Translation Initiation Factor eIF-2B complex with the Isohexide Diamine GSK735

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Translation initiation factor eIF-2B subunit alpha	polymer	305	33754.1	1	UniProt (Q14232) Pfam (PF01008)	Homo sapiens (human)	eIF-2B GDP-GTP exchange factor subunit alpha
2	B (B)	Translation initiation factor eIF-2B subunit beta	polymer	351	39039.5	1	UniProt (P49770) Pfam (PF01008)	Homo sapiens (human)	S20I15,S20III15,eIF-2B GDP-GTP exchange factor subunit beta
3	C (D)	Translation initiation factor eIF2B subunit delta	polymer	370	41192.3	1	UniProt (Q9UI10) Pfam (PF01008)	Homo sapiens (human)	eIF2B GDP-GTP exchange factor subunit delta
4	D (A)	PROLINE	non-polymer		115.1	1	Chemie (PRO) PubChem (145742)
5	E, H (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
6	F (B)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
7	G (B)	1,4:3,6-dianhydro-2,5-bis[2-(4-chlorophenoxy)acetamido]-2,5-dideoxy-D-glucitol	non-polymer		481.3	1	Chemie (A1C32)
8	I, J, K (A, B, D)	water	water		18.0	512	Chemie (HOH)

Sequence modifications

D: 164 - 523 (UniProt: Q9UI10)

PDB	External Database	Details
Met 163	-	initiating methionine
Ser 524	-	expression tag
Gly 525	-	expression tag
Gly 526	-	expression tag
His 527	-	expression tag
His 528	-	expression tag
His 529	-	expression tag
His 530	-	expression tag
His 531	-	expression tag
His 532	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	113986.0
Non-Polymers*	Number of molecules	5
	Total formula weight	850.6
All*	Total formula weight	114836.6

*Water molecules are not included.