9ZFL
Structure of an Engineered Sodium/Iodide Symporter (PF-NIS)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium/iodide cotransporter | polymer | 618 | 65308.9 | 1 | UniProt (Q63008) Pfam (PF00474) | Rattus norvegicus (rat) | Na(+)/I(-) cotransporter,Sodium-iodide symporter,Na(+)/I(-) symporter,Solute carrier family 5 member 5 |
| 2 | B (A) | PERRHENATE | non-polymer | 250.2 | 1 | Chemie (REO) | |||
| 3 | C, D (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 4 | E (A) | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A: 1 - 618 (UniProt: Q63008)
| PDB | External Database | Details |
|---|---|---|
| Gln 225 | Asn 225 | engineered mutation |
| Pro 253 | Leu 253 | engineered mutation |
| Phe 254 | Val 254 | engineered mutation |
| Gln 485 | Asn 485 | engineered mutation |
| Gln 497 | Asn 497 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 65308.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 296.2 | |
| All* | Total formula weight | 65605.1 |
