9ZFL
Structure of an Engineered Sodium/Iodide Symporter (PF-NIS)
Functional Information from PROSITE/UniProt
| site_id | PS00456 |
| Number of Residues | 26 |
| Details | NA_SOLUT_SYMP_1 Sodium:solute symporter family signature 1. GldIwasLLSTGIIctlYTtvGGMkA |
| Chain | Residue | Details |
| A | GLY161-ALA186 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Discontinuously helical; Name=2","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 77 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 67 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Discontinuously helical; Name=7","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=13","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
