9Z9E
Structure of FabS1CE2_ER-3c in complex with the extracellular region of EGFR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 625 | 69133.8 | 1 | UniProt (P00533) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (D) | heavy chain | polymer | 231 | 24696.6 | 1 | Homo sapiens | ||
| 3 | C (E) | light chain | polymer | 212 | 23198.7 | 1 | Homo sapiens | ||
| 4 | D, F, G (B, F, G) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E (C) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G07617FP) | |||
| 6 | H, I (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) PubChem (24139) | |||
| 7 | EA, J, P, R, T (E, A, D) | THIOCYANATE ION | non-polymer | 58.1 | 5 | Chemie (SCN) PubChem (9322) | |||
| 8 | HA, IA, JA, K, U... (E, A, D) | CHLORIDE ION | non-polymer | 35.5 | 8 | Chemie (CL) PubChem (312) | |||
| 9 | KA, L, LA, M, MA... (E, A, D) | SODIUM ION | non-polymer | 23.0 | 11 | Chemie (NA) PubChem (923) | |||
| 10 | AA, N (D, A) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) PubChem (813) | |||
| 11 | CA, DA, O, S (E, D) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) PubChem (8117) | |||
| 12 | Q (D) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 13 | BA, FA, GA (E) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 14 | RA, SA, TA (A, D, E) | water | water | 18.0 | 251 | Chemie (HOH) |
Sequence modifications
A: 1 - 621 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Leu 622 | - | expression tag |
| Val 623 | - | expression tag |
| Pro 624 | - | expression tag |
| Arg 625 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 117029.0 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2508.3 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 2108.4 | |
| All* | Total formula weight | 121645.7 |
