9YXD

Crystal structure of recombinant human follicle stimulating hormone in complex with an anti-FSH alpha Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Glycoprotein hormones alpha chain	polymer	92	10217.8	1	UniProt (P01215) Pfam (PF00236)	Homo sapiens (human)	Anterior pituitary glycoprotein hormones common subunit alpha,Choriogonadotropin alpha chain,Chorionic gonadotrophin subunit alpha,CG-alpha,Follicle-stimulating hormone alpha chain,FSH-alpha,Follitropin alpha chain,Luteinizing hormone alpha chain,LSH-alpha,Lutropin alpha chain,Thyroid-stimulating hormone alpha chain,TSH-alpha,Thyrotropin alpha chain
2	B (B)	Follitropin subunit beta	polymer	111	12500.2	1	UniProt (P01225) Pfam (PF00007)	Homo sapiens (human)	Follicle-stimulating hormone beta subunit,FSH-B,FSH-beta,Follitropin beta chain
3	C (C)	Fab light chain	polymer	220	24264.8	1		Mus musculus
4	D (D)	Fab heavy chain	polymer	225	24301.1	1		Mus musculus
5	E (K)	Ig-like domain-containing protein	polymer	127	14075.4	1		Lama glama
6	F (E)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
7	G, I, J (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
8	H (A)	2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		209.2	1	Chemie (BTB)
9	K (D)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
10	L, M, N, O, P (A, B, C, D, K)	water	water		18.0	319	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	85359.3
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	5
	Total formula weight	965.0
All*	Total formula weight	86748.6

*Water molecules are not included.