9YXD

Crystal structure of recombinant human follicle stimulating hormone in complex with an anti-FSH alpha Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000165	biological_process	MAPK cascade
A	0001541	biological_process	ovarian follicle development
A	0005179	molecular_function	hormone activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005796	cellular_component	Golgi lumen
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007283	biological_process	spermatogenesis
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009755	biological_process	hormone-mediated signaling pathway
A	0010469	biological_process	regulation of signaling receptor activity
A	0010893	biological_process	positive regulation of steroid biosynthetic process
A	0016913	molecular_function	follicle-stimulating hormone activity
A	0016914	cellular_component	follicle-stimulating hormone complex
A	0030335	biological_process	positive regulation of cell migration
A	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
A	0042699	biological_process	follicle-stimulating hormone signaling pathway
A	0043235	cellular_component	signaling receptor complex
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0061696	cellular_component	pituitary gonadotropin complex
B	0000165	biological_process	MAPK cascade
B	0001541	biological_process	ovarian follicle development
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0006701	biological_process	progesterone biosynthetic process
B	0007154	biological_process	cell communication
B	0007179	biological_process	transforming growth factor beta receptor signaling pathway
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007283	biological_process	spermatogenesis
B	0007292	biological_process	female gamete generation
B	0007565	biological_process	female pregnancy
B	0008284	biological_process	positive regulation of cell population proliferation
B	0010893	biological_process	positive regulation of steroid biosynthetic process
B	0016913	molecular_function	follicle-stimulating hormone activity
B	0016914	cellular_component	follicle-stimulating hormone complex
B	0023052	biological_process	signaling
B	0030335	biological_process	positive regulation of cell migration
B	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
B	0042699	biological_process	follicle-stimulating hormone signaling pathway
B	0043235	cellular_component	signaling receptor complex
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II

Functional Information from PROSITE/UniProt

site_id	PS00261
Number of Residues	7
Details	GLYCO_HORMONE_BETA_1 Glycoprotein hormones beta chain signature 1. CAGYCyT

Chain	Residue	Details
B	CYS28-THR34

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
C	TYR198-HIS204
D	TYR198-HIS204

---

site_id	PS00689
Number of Residues	28
Details	GLYCO_HORMONE_BETA_2 Glycoprotein hormones beta chain signature 2. PVAtqChCgkCdsdsTDCtvrglg..PsyC

Chain	Residue	Details
B	PRO77-CYS104

---

site_id	PS00779
Number of Residues	13
Details	GLYCO_HORMONE_ALPHA_1 Glycoprotein hormones alpha chain signature 1. CmGCCFSRAYPTP

Chain	Residue	Details
A	CYS28-PRO40

---

site_id	PS00780
Number of Residues	14
Details	GLYCO_HORMONE_ALPHA_2 Glycoprotein hormones alpha chain signature 2. NHTaChCsTCyyHK

Chain	Residue	Details
A	ASN78-LYS91

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000036","evidences":[{"source":"PubMed","id":"15662415","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24692546","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MQW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000037","evidences":[{"source":"PubMed","id":"15662415","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24692546","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MQW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15662415","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"4835136","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MQW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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