9YUB
The crystal structure of human abl1 T315I mutant kinase domain in complex with PH-ELV-1022
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase ABL1 | polymer | 290 | 33547.2 | 1 | UniProt (P00519) | Homo sapiens (human) | Abelson murine leukemia viral oncogene homolog 1,Abelson tyrosine-protein kinase 1,Proto-oncogene c-Abl,p150 |
| 2 | B (A) | (1S,2S)-N-[2-(4,6-dimethoxypyrimidin-5-yl)-1-methyl-1H-pyrrolo[2,3-c]pyridin-5-yl]-2-fluorocyclopropane-1-carboxamide | non-polymer | 371.4 | 1 | Chemie (A1CZ6) | |||
| 3 | C (A) | water | water | 18.0 | 90 | Chemie (HOH) |
Sequence modifications
A: 229 - 512 (UniProt: P00519)
| PDB | External Database | Details |
|---|---|---|
| Gly 223 | - | expression tag |
| Ala 224 | - | expression tag |
| Met 225 | - | expression tag |
| Asp 226 | - | expression tag |
| Pro 227 | - | expression tag |
| Ser 228 | - | expression tag |
| Ile 315 | Thr 315 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33547.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 371.4 | |
| All* | Total formula weight | 33918.6 |
