9YRX

Crystal structure of Cysteinyl-tRNA synthetase (CysRS) from Plasmodium falciparum in complex with Cysteine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Cysteine--tRNA ligase	polymer	466	54533.2	2	UniProt (Q8IJP3) Pfam (PF01406)	Plasmodium falciparum 3D7	Cysteinyl-tRNA synthetase
2	C, E, J, K (A, B)	MALONATE ION	non-polymer		102.0	4	Chemie (MLI)
3	D, I (A, B)	CYSTEINE	non-polymer		121.2	2	Chemie (CYS)
4	F, L (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	G, H, M, N (A, B)	SODIUM ION	non-polymer		23.0	4	Chemie (NA)
6	O, P (A, B)	water	water		18.0	212	Chemie (HOH)

Sequence modifications

A, B: 14 - 458 (UniProt: Q8IJP3)

PDB	External Database	Details
Met -7	-	initiating methionine
Ala -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Met 1	-	expression tag
Gly 2	-	expression tag
Thr 3	-	expression tag
Leu 4	-	expression tag
Glu 5	-	expression tag
Ala 6	-	expression tag
Gln 7	-	expression tag
Thr 8	-	expression tag
Gln 9	-	expression tag
Gly 10	-	expression tag
Pro 11	-	expression tag
Gly 12	-	expression tag
Ser 13	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	109066.4
Non-Polymers*	Number of molecules	12
	Total formula weight	873.3
All*	Total formula weight	109939.7

*Water molecules are not included.