9YRO
Cryo-EM structure of SARS-CoV-2 nsp10-nsp14 (E191A) in complex with T20P14-S complex, monomeric form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Non-structural protein 10 | polymer | 139 | 14802.9 | 1 | UniProt (P0DTD1) | Severe acute respiratory syndrome coronavirus 2 | nsp10,Growth factor-like peptide,GFL |
| 2 | B (B) | Proofreading exoribonuclease | polymer | 527 | 59829.4 | 1 | UniProt (P0DTD1) | Severe acute respiratory syndrome coronavirus 2 | ExoN,Guanine-N7 methyltransferase,Non-structural protein 14,nsp14 |
| 3 | C (E) | T20P14-S RNA | polymer | 34 | 10916.5 | 1 | Severe acute respiratory syndrome coronavirus 2 | ||
| 4 | D, E, G, H, I (A, B) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 5 | F (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | J (E) | [(2~{R},3~{R},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate | non-polymer | 340.2 | 1 | Chemie (K5X) |
Sequence modifications
B: 1 - 527 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ala 191 | Glu 6116 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 85548.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 691.5 | |
| All* | Total formula weight | 86240.4 |
