9YR9

Structure of human MARK3 in complex with inhibitor

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	MAP/microtubule affinity-regulating kinase 3	polymer	325	37433.4	2	UniProt (P27448)	Homo sapiens (human)	C-TAK1,cTAK1,Cdc25C-associated protein kinase 1,ELKL motif kinase 2,EMK-2,Protein kinase STK10,Ser/Thr protein kinase PAR-1,Par-1a,Serine/threonine-protein kinase p78
2	C, D (A, B)	3-({5-chloro-2-[2-(difluoromethoxy)-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl}amino)thiophene-2-carboxamide	non-polymer		510.0	2	Chemie (A1CZY)
3	E, F (A, B)	water	water		18.0	196	Chemie (HOH)

Sequence modifications

A, B: 48 - 367 (UniProt: P27448)

PDB	External Database	Details
Gly 43	-	expression tag
Ala 44	-	expression tag
Met 45	-	expression tag
Asp 46	-	expression tag
Pro 47	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74866.7
Non-Polymers*	Number of molecules	2
	Total formula weight	1019.9
All*	Total formula weight	75886.7

*Water molecules are not included.