9YNH
Full-length human cytoplasmic dynein-1 in phi-like state bound to dynactin-p150glued and LIS1
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cytoplasmic dynein 1 heavy chain 1 | polymer | 4646 | 533083.3 | 2 | UniProt (Q14204) | Homo sapiens (human) | Cytoplasmic dynein heavy chain 1,Dynein heavy chain,cytosolic |
| 2 | C, D, O, P (C, D, U, V) | Cytoplasmic dynein 1 intermediate chain 2 | polymer | 638 | 71546.4 | 4 | UniProt (Q13409) | Homo sapiens (human) | Cytoplasmic dynein intermediate chain 2,Dynein intermediate chain 2,cytosolic,DH IC-2 |
| 3 | E, F (E, F) | Cytoplasmic dynein 1 light intermediate chain 2 | polymer | 492 | 54173.2 | 2 | UniProt (O43237) | Homo sapiens (human) | Dynein light intermediate chain 2,cytosolic,LIC-2,LIC53/55 |
| 4 | G, H (G, H) | Dynein light chain roadblock-type 1 | polymer | 96 | 10934.6 | 2 | UniProt (Q9NP97) | Homo sapiens (human) | Bithoraxoid-like protein,BLP,Dynein light chain 2A,cytoplasmic,Dynein-associated protein Km23,Roadblock domain-containing protein 1 |
| 5 | I, J (I, J) | Dynein light chain 1, cytoplasmic | polymer | 89 | 10381.9 | 2 | UniProt (P63167) | Homo sapiens (human) | 8 kDa dynein light chain,DLC8,Dynein light chain LC8-type 1,Protein inhibitor of neuronal nitric oxide synthase,PIN |
| 6 | K, L (K, L) | Dynein light chain Tctex-type 1 | polymer | 113 | 12462.0 | 2 | UniProt (P63172) | Homo sapiens (human) | Protein CW-1,T-complex testis-specific protein 1 homolog |
| 7 | M, N (O, P) | Platelet-activating factor acetylhydrolase IB subunit beta | polymer | 410 | 46710.0 | 2 | UniProt (P43034) | Homo sapiens (human) | Lissencephaly-1 protein,LIS-1,PAF acetylhydrolase 45 kDa subunit,PAF-AH 45 kDa subunit,PAF-AH alpha,PAFAH alpha |
| 8 | Q, R (W, X) | Dynactin subunit 1 | polymer | 1281 | 142015.5 | 2 | UniProt (Q14203) | Homo sapiens (human) | 150 kDa dynein-associated polypeptide,DAP-150,DP-150,p135,p150-glued |
| 9 | AA, BA, S, U, V... (B, A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 6 | Chemie (ADP) | |||
| 10 | T, Z (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 11 | CA, DA, W, X (B, A) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) |
Sequence modifications
W, X: 1 - 1281 (UniProt: Q14203)
| PDB | External Database | Details |
|---|---|---|
| Arg 118 | Lys 118 | conflict |
| Ser 124 | Thr 124 | conflict |
| Asn 125 | Thr 125 | conflict |
| Pro 134 | Leu 134 | conflict |
| Ala 200 | Val 200 | conflict |
| Ala 207 | Val 207 | conflict |
| Asp 631 | Glu 631 | conflict |
| Ser 742 | Cys 742 | conflict |
| Ser 778 | Thr 778 | conflict |
| Ala 821 | Pro 821 | conflict |
| Pro 862 | Leu 862 | conflict |
| Ile 1048 | Leu 1048 | conflict |
| Gly 1072 | Ala 1072 | conflict |
| Ala 1073 | Ile 1073 | conflict |
| Ile 1080 | Ser 1080 | conflict |
| Val 1113 | Ile 1113 | conflict |
| Ala 1125 | Ser 1125 | conflict |
| Leu 1136 | - | insertion |
| Pro 1137 | - | insertion |
| Pro 1138 | - | insertion |
| Ala 1147 | Pro 1144 | conflict |
| Asn 1156 | Ser 1153 | conflict |
| Ser 1177 | Thr 1174 | conflict |
| Leu 1189 | Met 1186 | conflict |
| Thr 1193 | Ala 1190 | conflict |
| Ile 1202 | Val 1199 | conflict |
| Leu 1259 | Phe 1256 | conflict |
| Asp 1277 | Ser 1274 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 1905706.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3674.8 | |
| All* | Total formula weight | 1909381.3 |
