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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9YNH

Full-length human cytoplasmic dynein-1 in phi-like state bound to dynactin-p150glued and LIS1

This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
site_idPS00639
Number of Residues11
DetailsTHIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS
ChainResidueDetails
AILE2216-SER2226
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LASCsaDmTIKLWDF
ChainResidueDetails
OLEU165-PHE179
OILE207-VAL221
OLEU311-VAL325
OVAL395-CYS409
site_idPS00845
Number of Residues32
DetailsCAP_GLY_1 CAP-Gly domain signature. Gatlfatgk..WvGVilDeak....GKNdGTvqGrkYF
ChainResidueDetails
WGLY48-PHE79
site_idPS01239
Number of Residues15
DetailsDYNEIN_LIGHT_1 Dynein light chain type 1 signature. HcIvGRnFGSyVTHE
ChainResidueDetails
IHIS55-GLU69
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues302
DetailsRegion: {"description":"Interaction with DYNC1LI2","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues462
DetailsRegion: {"description":"AAA 1","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues498
DetailsRegion: {"description":"AAA 3","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues538
DetailsRegion: {"description":"AAA 4","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues458
DetailsRegion: {"description":"AAA 5","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues432
DetailsRegion: {"description":"AAA 6","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues454
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues70
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues10
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9JHU4","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues180
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues158
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues160
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues158
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues149
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues162
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues142
DetailsRepeat: {"description":"WD 7"}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues44
DetailsRegion: {"description":"Interaction with ESR1","evidences":[{"source":"PubMed","id":"15891768","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15193260","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30464262","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37696958","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues144
DetailsRegion: {"description":"Interaction with GNB1","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues2
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues64
DetailsDomain: {"description":"LisH","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues130
DetailsRegion: {"description":"Interaction with NDE1","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues74
DetailsRegion: {"description":"Required for self-association and interaction with PAFAH1B2 and PAFAH1B3","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues84
DetailsRegion: {"description":"Interaction with DCX","evidences":[{"source":"PubMed","id":"11001923","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues44
DetailsRegion: {"description":"Interaction with NDEL1","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

248335

PDB entries from 2026-01-28

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