9YKS
Crystal structure of the G9a (EHMT2) SET domain in complex with SAM and TNG917
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Histone-lysine N-methyltransferase EHMT2 | polymer | 282 | 32517.8 | 4 | UniProt (Q96KQ7) Pfam (PF05033) Pfam (PF00856) | Homo sapiens (human) | Euchromatic histone-lysine N-methyltransferase 2,HLA-B-associated transcript 8,Histone H3-K9 methyltransferase 3,H3-K9-HMTase 3,Lysine N-methyltransferase 1C,Protein G9a |
| 2 | AA, BA, CA, E, F... (C, A, D, B) | ZINC ION | non-polymer | 65.4 | 16 | Chemie (ZN) PubChem (32051) | |||
| 3 | DA, I, MA, S (C, A, D, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 4 | Chemie (SAM) | |||
| 4 | EA, J, NA, T (C, A, D, B) | N~2~-[(7M)-6-fluoro-7-(2,5,6,7-tetrahydro-1H-azepin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]-N~4~,6-dimethylpyrimidine-2,4-diamine | non-polymer | 369.4 | 4 | Chemie (A1CXM) PubChem (168224398) | |||
| 5 | FA, GA, HA, K, L... (C, A, D, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 13 | Chemie (EDO) | |||
| 6 | U, V (B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) PubChem (753) | |||
| 7 | RA, SA, TA, UA (A, B, C, D) | water | water | 18.0 | 1029 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 130071.4 | |
| Non-Polymers* | Number of molecules | 39 |
| Total formula weight | 5109.1 | |
| All* | Total formula weight | 135180.5 |
