9YKS
Crystal structure of the G9a (EHMT2) SET domain in complex with SAM and TNG917
This is a non-PDB format compatible entry.
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 252 |
| Details | Domain: {"description":"Pre-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00157","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 351 |
| Details | Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 64 |
| Details | Domain: {"description":"Post-SET"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 69 |
| Details | Region: {"description":"Interaction with histone H3","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 64 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20084102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24900801","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2O8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NVQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20084102","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2O8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NVQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27648579","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5T0M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20084102","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2O8J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Site: {"description":"Histone H3K9me binding","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
