9YC6
Mutant human uPAR bound to the Fab fragment of the targeted cancer therapeutic antibody FL1
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Anti-uPAR antibody FL1 Fab light chain | polymer | 219 | 24168.8 | 1 | Mus musculus (Mouse) | ||
| 2 | B (U) | Urokinase plasminogen activator surface receptor | polymer | 283 | 31455.4 | 1 | UniProt (Q03405) | Homo sapiens (human) | U-PAR,uPAR,Monocyte activation antigen Mo3 |
| 3 | C (H) | Anti-uPAR antibody FL1 Fab heavy chain | polymer | 221 | 23581.3 | 1 | Mus musculus (Mouse) | ||
| 4 | D (A) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 5 | E (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 6 | F, G (U) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
U: 1 - 283 (UniProt: Q03405)
| PDB | External Database | Details |
|---|---|---|
| Cys 47 | His 69 | engineered mutation |
| Cys 259 | Asn 281 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 79205.5 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1010.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 80658.8 |
