9YC6
Mutant human uPAR bound to the Fab fragment of the targeted cancer therapeutic antibody FL1
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| U | 0001934 | biological_process | positive regulation of protein phosphorylation |
| U | 0005102 | molecular_function | signaling receptor binding |
| U | 0005515 | molecular_function | protein binding |
| U | 0005576 | cellular_component | extracellular region |
| U | 0005788 | cellular_component | endoplasmic reticulum lumen |
| U | 0005789 | cellular_component | endoplasmic reticulum membrane |
| U | 0005886 | cellular_component | plasma membrane |
| U | 0005925 | cellular_component | focal adhesion |
| U | 0006935 | biological_process | chemotaxis |
| U | 0007160 | biological_process | cell-matrix adhesion |
| U | 0007165 | biological_process | signal transduction |
| U | 0007596 | biological_process | blood coagulation |
| U | 0008047 | molecular_function | enzyme activator activity |
| U | 0009897 | cellular_component | external side of plasma membrane |
| U | 0009986 | cellular_component | cell surface |
| U | 0010755 | biological_process | regulation of plasminogen activation |
| U | 0016020 | cellular_component | membrane |
| U | 0019898 | cellular_component | extrinsic component of membrane |
| U | 0019899 | molecular_function | enzyme binding |
| U | 0019904 | molecular_function | protein domain specific binding |
| U | 0030155 | biological_process | regulation of cell adhesion |
| U | 0030162 | biological_process | regulation of proteolysis |
| U | 0030377 | molecular_function | urokinase plasminogen activator receptor activity |
| U | 0031639 | biological_process | plasminogen activation |
| U | 0034112 | biological_process | positive regulation of homotypic cell-cell adhesion |
| U | 0034394 | biological_process | protein localization to cell surface |
| U | 0035579 | cellular_component | specific granule membrane |
| U | 0038023 | molecular_function | signaling receptor activity |
| U | 0038195 | biological_process | urokinase plasminogen activator signaling pathway |
| U | 0043066 | biological_process | negative regulation of apoptotic process |
| U | 0043388 | biological_process | positive regulation of DNA binding |
| U | 0045742 | biological_process | positive regulation of epidermal growth factor receptor signaling pathway |
| U | 0051917 | biological_process | regulation of fibrinolysis |
| U | 0090091 | biological_process | positive regulation of extracellular matrix disassembly |
| U | 0090200 | biological_process | positive regulation of release of cytochrome c from mitochondria |
| U | 0098634 | molecular_function | cell-matrix adhesion mediator activity |
| U | 2000117 | biological_process | obsolete negative regulation of cysteine-type endopeptidase activity |
| U | 2001243 | biological_process | negative regulation of intrinsic apoptotic signaling pathway |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR197-HIS203 |
| site_id | PS00983 |
| Number of Residues | 46 |
| Details | LY6_UPAR Ly-6 / u-PAR domain signature. RCMqCktngd...Crve.....ECAlgqdlCrttivrlweegeelelveksct..C |
| Chain | Residue | Details |
| U | ARG2-CYS47 | |
| U | GLU94-CYS147 | |
| U | GLN193-CYS247 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 91 |
| Details | Domain: {"description":"UPAR/Ly6 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 98 |
| Details | Domain: {"description":"UPAR/Ly6 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 91 |
| Details | Domain: {"description":"UPAR/Ly6 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Cleavage; by U-PA"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"GPI-anchor amidated glycine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15861141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16456079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22285761","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15861141","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15861141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16456079","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22285761","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
