9YB5
Cryo-EM structure of human importin Beta:Ran-GDP:RanBP1 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Importin subunit beta-1 | polymer | 458 | 51071.1 | 1 | UniProt (Q14974) Pfam (PF03810) Pfam (PF00514) | Homo sapiens (human) | Importin-90,Karyopherin subunit beta-1,Nuclear factor p97,Pore targeting complex 97 kDa subunit,PTAC97 |
| 2 | B (D) | GTP-binding nuclear protein Ran | polymer | 210 | 23712.3 | 1 | UniProt (P62826) Pfam (PF00071) | Homo sapiens (human) | Androgen receptor-associated protein 24,GTPase Ran,Ras-like protein TC4,Ras-related nuclear protein |
| 3 | C (C) | Ran-specific GTPase-activating protein | polymer | 136 | 16109.4 | 1 | UniProt (P43487) Pfam (PF00638) | Homo sapiens (human) | Ran-binding protein 1,RanBP1 |
| 4 | D (D) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E (D) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) |
Sequence modifications
D: 8 - 213 (UniProt: P62826)
C: 27 - 160 (UniProt: P43487)
| PDB | External Database | Details |
|---|---|---|
| Ala 6 | - | expression tag |
| Ala 7 | - | expression tag |
| Ala 214 | - | expression tag |
| Ala 215 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Pro 25 | - | expression tag |
| Asp 26 | - | expression tag |
| Ala 31 | Lys 39 | conflict |
| Cys 42 | Lys 50 | conflict |
| Asn 43 | Met 51 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 90892.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 467.5 | |
| All* | Total formula weight | 91360.3 |
