9Y4W
Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (active-like-state) asymmetrically bound to the viral effector AcP10
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Translation initiation factor eIF-2B subunit epsilon | polymer | 721 | 80466.6 | 2 | UniProt (Q13144) Pfam (PF02020) | Homo sapiens (human) | eIF-2B GDP-GTP exchange factor subunit epsilon |
| 2 | C, D (C, D) | Translation initiation factor eIF2B subunit beta | polymer | 355 | 39438.9 | 2 | UniProt (P49770) Pfam (PF01008) | Homo sapiens (human) | S20I15,S20III15,eIF2B GDP-GTP exchange factor subunit beta |
| 3 | E, F (E, F) | Translation initiation factor eIF-2B subunit delta | polymer | 523 | 57640.2 | 2 | UniProt (Q9UI10) Pfam (PF01008) | Homo sapiens (human) | eIF-2B GDP-GTP exchange factor subunit delta |
| 4 | G, H (G, H) | Translation initiation factor eIF-2B subunit alpha | polymer | 305 | 33754.1 | 2 | UniProt (Q14232) Pfam (PF01008) | Homo sapiens (human) | eIF-2B GDP-GTP exchange factor subunit alpha |
| 5 | I, J (I, J) | Translation initiation factor eIF-2B subunit gamma | polymer | 452 | 50304.2 | 2 | UniProt (Q9NR50) Pfam (PF00483) Pfam (PF25084) | Homo sapiens (human) | eIF-2B GDP-GTP exchange factor subunit gamma |
| 6 | K (K) | Uridine kinase P10 | polymer | 210 | 23715.6 | 1 | UniProt (B2BW43) Pfam (PF00485) | Beluga whale coronavirus SW1 | Accessory protein P10,AcP10 |
| 7 | L, O, R (B, E, J) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) PubChem (312) | |||
| 8 | M, N, S (C, D, K) | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) PubChem (1061) | |||
| 9 | P, Q (E, J) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) PubChem (32051) | |||
| 10 | T, U (G, H) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
C, D: 2 - 351 (UniProt: P49770)
| PDB | External Database | Details |
|---|---|---|
| Met -16 | - | initiating methionine |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Ser -6 | - | expression tag |
| Glu -5 | - | expression tag |
| Asn -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Tyr -2 | - | expression tag |
| Phe -1 | - | expression tag |
| Gln 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Gly 100 | Ser 100 | linker |
| Ser 101 | Asp 101 | linker |
| Gly 102 | Glu 102 | linker |
| - | Asp 104 | deletion |
| - | Gln 105 | deletion |
| - | Gln 106 | deletion |
| - | Glu 107 | deletion |
| - | Ser 108 | deletion |
| - | Leu 109 | deletion |
| - | His 110 | deletion |
| - | Lys 111 | deletion |
| - | Leu 112 | deletion |
| - | Leu 113 | deletion |
| - | Thr 114 | deletion |
| - | Ser 115 | deletion |
| - | Gly 116 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 546923.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 522.1 | |
| All* | Total formula weight | 547445.8 |
