9XY4
Zymogen ADAM17- iRhom1 Cytoplasmic Deletion (370) Complex Bound by the MEDI3622 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Inactive rhomboid protein 1 | polymer | 429 | 48959.5 | 1 | UniProt (Q96CC6) Pfam (PF01694) | Homo sapiens (human) | iRhom1,Epidermal growth factor receptor-related protein,Rhomboid 5 homolog 1,Rhomboid family member 1,p100hRho |
| 2 | B (C) | MEDI3622 Fab Heavy Chain | polymer | 214 | 23324.9 | 1 | Homo sapiens (human) | ||
| 3 | C (D) | MEDI3622 Fab Light Chain | polymer | 216 | 22900.7 | 1 | Homo sapiens (human) | ||
| 4 | D (B) | Disintegrin and metalloproteinase domain-containing protein 17 | polymer | 671 | 76130.9 | 1 | UniProt (P78536) Pfam (PF13574) Pfam (PF00200) Pfam (PF16698) | Homo sapiens (human) | ADAM 17,Snake venom-like protease,TNF-alpha convertase,TNF-alpha-converting enzyme |
| 5 | E (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 6 | F (B) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) PubChem (271) | |||
| 7 | G (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) PubChem (32051) | |||
| 8 | H, I, J, K, L... (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) PubChem (24139) |
Sequence modifications
B: 28 - 698 (UniProt: P78536)
| PDB | External Database | Details |
|---|---|---|
| Ala 406 | Glu 406 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 171316.0 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1432.7 | |
| All* | Total formula weight | 173173.1 |
