9XJP
Structure of the CX3CL1.44-US28-GqiN18-scFv16 in the E-state, chemokine domain fully modeled
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha | polymer | 352 | 41249.9 | 1 | UniProt (P63096) UniProt (P50148) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein,Guanine nucleotide-binding protein alpha-q |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37728.2 | 1 | UniProt (P62873) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 67 | 7432.6 | 1 | UniProt (P59768) | Homo sapiens (human) | G gamma-I |
| 4 | D (D) | Antibody fragment scFv16 | polymer | 256 | 27340.5 | 1 | Mus musculus | ||
| 5 | E (R) | G-protein coupled receptor homolog US28 | polymer | 362 | 42041.1 | 1 | UniProt (P69332) | Human betaherpesvirus 5 | HHRF3 |
| 6 | F (L) | Processed fractalkine | polymer | 91 | 10072.6 | 1 | UniProt (P78423) | Homo sapiens (human) | engineered fractalkine CX3CL1.44 |
| 7 | G (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 8 | H, I (R) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) PubChem (5997) |
Sequence modifications
A: 1 - 17 (UniProt: P63096)
A: 18 - 359 (UniProt: P50148)
B: 2 - 340 (UniProt: P62873)
R: 1 - 354 (UniProt: P69332)
L: 1 - 77 (UniProt: P78423)
A: 18 - 359 (UniProt: P50148)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Lys -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Ala 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Val 1 | Gln 25 | engineered mutation |
| Arg 2 | His 26 | engineered mutation |
| Pro 3 | His 27 | engineered mutation |
| His 4 | Gly 28 | engineered mutation |
| Ile 5 | Val 29 | engineered mutation |
| Asn 6 | Thr 30 | engineered mutation |
| Asn 7 | Lys 31 | engineered mutation |
| Ser 78 | - | expression tag |
| Gly 79 | - | expression tag |
| Ser 80 | - | expression tag |
| Gly 81 | - | expression tag |
| Ser 82 | - | expression tag |
| Ala 83 | - | expression tag |
| Ala 84 | - | expression tag |
| Ala 85 | - | expression tag |
| Leu 86 | - | expression tag |
| Glu 87 | - | expression tag |
| Val 88 | - | expression tag |
| Leu 89 | - | expression tag |
| Phe 90 | - | expression tag |
| Gln 91 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 165864.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1216.5 | |
| All* | Total formula weight | 167081.3 |
