9WZO
Crystal structure of 5-HT2AR in complex with antipsychotic drug pimavanserin
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562 | polymer | 394 | 44341.9 | 1 | UniProt (P28223) UniProt (P0ABE7) Pfam (PF00001) | Homo sapiens (human) | 5-HT-2,5-HT-2A,Serotonin receptor 2A,Cytochrome b-562 |
| 2 | B, C, G (A) | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) PubChem (5997) | |||
| 3 | D (A) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) PubChem (62551) | |||
| 4 | E, F, J, K (A) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 4 | Chemie (OLC) PubChem (11451146) | |||
| 5 | H (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 6 | I (A) | Pimavanserin | non-polymer | 427.6 | 1 | Chemie (A1L11) PubChem (10071196) | |||
| 7 | L (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) PubChem (8117) |
Sequence modifications
A: 67 - 265 (UniProt: P28223)
A: 1001 - 1106 (UniProt: P0ABE7)
A: 313 - 401 (UniProt: P28223)
| PDB | External Database | Details |
|---|---|---|
| Lys 162 | Ser 162 | engineered mutation |
| Trp 164 | Met 164 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Trp 1007 | Met 29 | engineered mutation |
| Ile 1098 | Arg 120 | engineered mutation |
| Ile 1102 | His 124 | engineered mutation |
| Gly 1106 | Arg 128 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 372 | Ser 372 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 44341.9 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 3382.4 | |
| All* | Total formula weight | 47724.3 |
