9WSV
Cryo-EM structure of DAMGO-muOR-arrestin-1-Fab30 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Mu-type opioid receptor,Vasopressin V2 receptor | polymer | 386 | 43316.1 | 1 | UniProt (P42866) UniProt (P30518) Pfam (PF00001) | Mus musculus (house mouse) | M-OR-1,MOR-1,V2R,AVPR V2,Antidiuretic hormone receptor,Renal-type arginine vasopressin receptor |
| 2 | B (C) | Beta-arrestin-1 | polymer | 393 | 44135.3 | 1 | UniProt (P17870) Pfam (PF00339) Pfam (PF02752) | Bos taurus (domestic cattle) | Arrestin beta-1,Arrestin-2 |
| 3 | C (H) | Fab30 heavy chain | polymer | 236 | 25333.2 | 1 | synthetic construct | ||
| 4 | D (L) | Fab30 light chain | polymer | 216 | 23566.3 | 1 | synthetic construct | ||
| 5 | E (P) | DAMGO | polymer | 5 | 513.6 | 1 | BIRD (PRD_002308) | synthetic construct | |
| 6 | F, G (R, P) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
R: 6 - 351 (UniProt: P42866)
R: 351 - 378 (UniProt: P30518)
C: 1 - 393 (UniProt: P17870)
| PDB | External Database | Details |
|---|---|---|
| Gly 3 | - | expression tag |
| Pro 4 | - | expression tag |
| Met 5 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Leu 379 | - | expression tag |
| Glu 380 | - | expression tag |
| Val 381 | - | expression tag |
| Leu 382 | - | expression tag |
| Phe 383 | - | expression tag |
| Gln 384 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 169 | Arg 169 | conflict |
| Ala 386 | Ile 386 | conflict |
| Ala 387 | Val 387 | conflict |
| Ala 388 | Phe 388 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 136864.5 | |
| All* | Total formula weight | 136864.5 |
