9WQL
GRM5-Gq Complex Structure
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (X, Y) | Metabotropic glutamate receptor 5 | polymer | 850 | 95310.0 | 2 | UniProt (P41594) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) | Homo sapiens (human) | mGluR5 |
| 2 | C (A) | miniGq | polymer | 246 | 28084.8 | 1 | Pfam (PF00503) UniProt (by SIFTS) (A0A590UJY2) | Homo sapiens | |
| 3 | D (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 4 | E (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 80 | 8506.8 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | F (F) | scFv16 | polymer | 260 | 27720.8 | 1 | Mus musculus | ||
| 6 | G (X) | 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide | non-polymer | 364.4 | 1 | Chemie (YKU) PubChem (11245456) | |||
| 7 | H, R (X, Y) | GAMMA-L-GLUTAMIC ACID | non-polymer | 147.1 | 2 | Chemie (GGL) | |||
| 8 | I, J, K, L, S... (X, Y) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) PubChem (24139) | |||
| 9 | M, W (X, Y) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) PubChem (312) | |||
| 10 | N, O, P, Q, X... (X, Y) | CHOLESTEROL | non-polymer | 386.7 | 7 | Chemie (CLR) PubChem (5997) |
Sequence modifications
X, Y: 21 - 839 (UniProt: P41594)
G: 1 - 71 (UniProt: P59768)
| PDB | External Database | Details |
|---|---|---|
| Met -10 | - | initiating methionine |
| Trp -9 | - | expression tag |
| Ser -8 | - | expression tag |
| His -7 | - | expression tag |
| Pro -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Phe -4 | - | expression tag |
| Glu -3 | - | expression tag |
| Lys -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Ser 2 | - | expression tag |
| Gly 3 | - | expression tag |
| Gly 4 | - | expression tag |
| Gly 5 | - | expression tag |
| Ser 6 | - | expression tag |
| Gly 7 | - | expression tag |
| Gly 8 | - | expression tag |
| Ser 9 | - | expression tag |
| Ala 10 | - | expression tag |
| Trp 11 | - | expression tag |
| Ser 12 | - | expression tag |
| His 13 | - | expression tag |
| Pro 14 | - | expression tag |
| Gln 15 | - | expression tag |
| Phe 16 | - | expression tag |
| Glu 17 | - | expression tag |
| Lys 18 | - | expression tag |
| Gly 19 | - | expression tag |
| Ser 20 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 72 | - | expression tag |
| Ser 73 | - | expression tag |
| Ala 74 | - | expression tag |
| Gly 75 | - | expression tag |
| Ser 76 | - | expression tag |
| Ala 77 | - | expression tag |
| Gly 78 | - | expression tag |
| Ser 79 | - | expression tag |
| Ala 80 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 292349.4 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 5205.8 | |
| All* | Total formula weight | 297555.2 |
