9WQA
5-HT2B receptor bound to IHCH-1906 in complex with an antibody obtained by cryo-electron microscopy (cryoEM)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5-hydroxytryptamine receptor 2B | polymer | 318 | 35582.2 | 1 | UniProt (P41595) | Homo sapiens (human) | 5-HT-2B,5-HT2B,Serotonin receptor 2B |
| 2 | B (B) | Anti-5-HT2B Fab light chain | polymer | 213 | 23151.8 | 1 | Homo sapiens | ||
| 3 | C (C) | Anti-5-HT2B Fab heavy chain | polymer | 247 | 26785.8 | 1 | Homo sapiens | ||
| 4 | D (A) | 1-(1,2,3,6-tetrahydropyridin-4-yl)-6,7,8,9-tetrahydro-5~{H}-benzo[7]annulen-4-ol | non-polymer | 243.3 | 1 | Chemie (A1EYE) |
Sequence modifications
A: 36 - 405 (UniProt: P41595)
| PDB | External Database | Details |
|---|---|---|
| Gly 29 | - | expression tag |
| Pro 30 | - | expression tag |
| Gly 31 | - | expression tag |
| Ser 32 | - | expression tag |
| Gly 33 | - | expression tag |
| Ser 34 | - | expression tag |
| Gly 35 | - | expression tag |
| Trp 144 | Met 144 | conflict |
| Arg 307 | Ala 248 | conflict |
| Leu 308 | Tyr 249 | conflict |
| - | Val 251 | deletion |
| - | Lys 252 | deletion |
| - | Asn 253 | deletion |
| - | Lys 254 | deletion |
| - | Pro 255 | deletion |
| - | Pro 256 | deletion |
| - | Gln 257 | deletion |
| - | Arg 258 | deletion |
| - | Leu 259 | deletion |
| - | Thr 260 | deletion |
| - | Trp 261 | deletion |
| - | Leu 262 | deletion |
| - | Thr 263 | deletion |
| - | Val 264 | deletion |
| - | Ser 265 | deletion |
| - | Thr 266 | deletion |
| - | Val 267 | deletion |
| - | Phe 268 | deletion |
| - | Gln 269 | deletion |
| - | Arg 270 | deletion |
| - | Asp 271 | deletion |
| - | Glu 272 | deletion |
| - | Thr 273 | deletion |
| - | Pro 274 | deletion |
| - | Cys 275 | deletion |
| - | Ser 276 | deletion |
| - | Ser 277 | deletion |
| - | Pro 278 | deletion |
| - | Glu 279 | deletion |
| - | Lys 280 | deletion |
| - | Val 281 | deletion |
| - | Ala 282 | deletion |
| - | Met 283 | deletion |
| - | Leu 284 | deletion |
| - | Asp 285 | deletion |
| - | Gly 286 | deletion |
| - | Ser 287 | deletion |
| - | Arg 288 | deletion |
| - | Lys 289 | deletion |
| - | Asp 290 | deletion |
| - | Lys 291 | deletion |
| - | Ala 292 | deletion |
| - | Leu 293 | deletion |
| - | Pro 294 | deletion |
| - | Asn 295 | deletion |
| - | Ser 296 | deletion |
| - | Gly 297 | deletion |
| - | Asp 298 | deletion |
| - | Glu 299 | deletion |
| - | Thr 300 | deletion |
| - | Leu 301 | deletion |
| - | Met 302 | deletion |
| - | Arg 303 | deletion |
| - | Arg 304 | deletion |
| - | Thr 305 | deletion |
| - | Ser 306 | deletion |
| - | Thr 307 | deletion |
| - | Ile 308 | deletion |
| - | Gly 309 | deletion |
| Ser 310 | Lys 310 | conflict |
| Gly 311 | Lys 311 | conflict |
| Arg 313 | Val 313 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 85519.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 243.3 | |
| All* | Total formula weight | 85763.1 |
