9WKX
[M322I] Menin complexed with DS-1594
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Menin | polymer | 488 | 54705.0 | 2 | UniProt (O00255) Pfam (PF05053) | Homo sapiens (human) | |
| 2 | C, G (A, B) | (1R,2S,4R)-4-[[4-(5,6-dimethoxypyridazin-3-yl)phenyl]methylamino]-2-[methyl-[6-[2,2,2-tris(fluoranyl)ethyl]thieno[2,3-d]pyrimidin-4-yl]amino]cyclopentan-1-ol | non-polymer | 574.6 | 2 | Chemie (7IX) PubChem (146636100) | |||
| 3 | D, E, H, I, J (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 4 | F (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 220 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 457 (UniProt: O00255)
A, B: 458 - 489 (UniProt: O00255)
| PDB | External Database | Details |
|---|---|---|
| Thr 5 | Ala 5 | engineered mutation |
| Ile 322 | Met 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 109410.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1483.9 | |
| All* | Total formula weight | 110893.9 |
