9WIJ

Cryo-EM structure of GPR84 with GLPG1205

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	G-protein coupled receptor 84,Soluble cytochrome b562	polymer	447	50237.6	1	UniProt (Q9NQS5) UniProt (P0ABE7)	Homo sapiens (human)	Inflammation-related G-protein coupled receptor EX33,Cytochrome b-562
2	B (A)	9-(2-cyclopropylethynyl)-2-[[(2~{S})-1,4-dioxan-2-yl]methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one	non-polymer		378.4	1	Chemie (A1L93)

Sequence modifications

A: 2 - 220 (UniProt: Q9NQS5)

PDB	External Database	Details
Met -22	-	initiating methionine
Lys -21	-	expression tag
Thr -20	-	expression tag
Ile -19	-	expression tag
Ile -18	-	expression tag
Ala -17	-	expression tag
Leu -16	-	expression tag
Ser -15	-	expression tag
Tyr -14	-	expression tag
Ile -13	-	expression tag
Phe -12	-	expression tag
Cys -11	-	expression tag
Leu -10	-	expression tag
Val -9	-	expression tag
Phe -8	-	expression tag
Ala -7	-	expression tag
Asp -6	-	expression tag
Tyr -5	-	expression tag
Lys -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Asp 0	-	expression tag
Lys 1	-	expression tag

A: 1000 - 1103 (UniProt: P0ABE7)

PDB	External Database	Details
Trp 1005	Met 29	conflict
Ile 1100	His 124	conflict
Leu 1104	-	linker
Glu 1105	-	linker
Arg 1106	-	linker
Ala 1107	-	linker
Arg 1108	-	linker
Ser 1109	-	linker
Thr 1110	-	linker
Leu 1111	-	linker
Gln 1112	-	linker
Lys 1113	-	linker
Glu 1114	-	linker
Val 1115	-	linker

A: 309 - 396 (UniProt: Q9NQS5)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	50237.6
Non-Polymers*	Number of molecules	1
	Total formula weight	378.4
All*	Total formula weight	50616.0

*Water molecules are not included.