9WAK
Cryo-EM structure of a human sodium pump W931R mutant in ouabain-bound E2P state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium/potassium-transporting ATPase subunit alpha-1 | polymer | 985 | 108816.9 | 1 | UniProt (P05023) Pfam (PF00690) Pfam (PF00122) Pfam (PF13246) Pfam (PF00689) | Homo sapiens (human) | Na(+)/K(+) ATPase alpha-1 subunit,Sodium pump subunit alpha-1 |
| 2 | B (B) | Sodium/potassium-transporting ATPase subunit beta-1 | polymer | 303 | 35108.3 | 1 | UniProt (P05026) Pfam (PF00287) | Homo sapiens (human) | Sodium/potassium-dependent ATPase subunit beta-1 |
| 3 | C (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 4 | D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | F (A) | OUABAIN | non-polymer | 584.7 | 1 | Chemie (OBN) PubChem (439501) | |||
| 6 | G, H, I, J, K... (A, B) | CHOLESTEROL | non-polymer | 386.7 | 12 | Chemie (CLR) PubChem (5997) | |||
| 7 | S (A) | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
A: 39 - 1023 (UniProt: P05023)
| PDB | External Database | Details |
|---|---|---|
| Arg 931 | Trp 931 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 143925.2 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 5296.1 | |
| All* | Total formula weight | 149221.3 |
