9W8S
Structure of mammalian RNA polymerase II stalled by a cisplatin-induced inter-strand crosslink lesion at the +2 position.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA-directed RNA polymerase II subunit RPB1 | polymer | 1970 | 217450.1 | 1 | Sus scrofa (pig) | ||
| 2 | B (B) | DNA-directed RNA polymerase subunit beta | polymer | 1174 | 134041.4 | 1 | UniProt (I3LGP4) | Sus scrofa (pig) | |
| 3 | C (C) | DNA-directed RNA polymerase II subunit RPB3 | polymer | 271 | 30997.6 | 1 | UniProt (I3LCH3) | Sus scrofa (pig) | DNA-directed RNA polymerase II subunit C |
| 4 | D (D) | DNA-directed RNA polymerase II subunit RPB4 | polymer | 142 | 16331.3 | 1 | UniProt (A0A481BYI6) | Sus scrofa (pig) | DNA-directed RNA polymerase II subunit D,DNA-directed RNA polymerase II subunit rpb4 |
| 5 | E (E) | DNA-directed RNA polymerases I, II, and III subunit RPABC1 | polymer | 210 | 24644.3 | 1 | UniProt (I3LSI7) | Sus scrofa (pig) | DNA-directed RNA polymerase II subunit E,RPB5 homolog |
| 6 | F (F) | DNA-directed RNA polymerases I, II, and III subunit RPABC2 | polymer | 127 | 14477.0 | 1 | UniProt (A0A4X1VEK9) | Sus scrofa (pig) | DNA-directed RNA polymerase II subunit F,RPB6 homolog |
| 7 | G (G) | DNA-directed RNA polymerase subunit RPB7 | polymer | 171 | 19227.2 | 1 | Sus scrofa (pig) | ||
| 8 | H (H) | DNA-directed RNA polymerases I, II, and III subunit RPABC3 | polymer | 150 | 17162.3 | 1 | UniProt (I3LCB2) | Sus scrofa (pig) | |
| 9 | I (I) | DNA-directed RNA polymerase II subunit RPB9 | polymer | 125 | 14541.2 | 1 | UniProt (P60899) | Sus scrofa (pig) | RNA polymerase II subunit B9,DNA-directed RNA polymerase II subunit I,RNA polymerase II 14.5 kDa subunit,RPB14.5 |
| 10 | J (J) | DNA-directed RNA polymerases I, II, and III subunit RPABC5 | polymer | 67 | 7655.1 | 1 | UniProt (A0A4X1VYD0) | Sus scrofa (pig) | DNA-directed RNA polymerase III subunit L |
| 11 | K (K) | DNA-directed RNA polymerase II subunit RPB11-a | polymer | 115 | 13068.0 | 1 | UniProt (F1RKE4) | Sus scrofa (pig) | |
| 12 | L (L) | DNA-directed RNA polymerases I, II, and III subunit RPABC4 | polymer | 58 | 7018.2 | 1 | UniProt (A0A4X1TRS6) | Sus scrofa (pig) | DNA-directed RNA polymerase II subunit K |
| 13 | M (N) | DNA (NTS, non-template strand) | polymer | 18 | 5712.7 | 1 | synthetic construct | ||
| 14 | N (P) | RNA (5'-R(*UP*AP*CP*AP*AP*UP*GP*UP*UP*GP*GP*AP*AP*AP*GP*GP*AP*GP*AP*G)-3') | polymer | 20 | 6535.0 | 1 | synthetic construct | ||
| 15 | O (T) | DNA (TS, template strand) | polymer | 25 | 7389.7 | 1 | synthetic construct | ||
| 16 | P, Q, R, S, T... (A, B, C, I, J...) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) PubChem (32051) | |||
| 17 | X (N) | Cisplatin | non-polymer | 300.0 | 1 | Chemie (CPT) | |||
| 18 | Y (P) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 15 |
| Total formula weight | 536251.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 847.6 | |
| All* | Total formula weight | 537098.8 |
