9W8S
Structure of mammalian RNA polymerase II stalled by a cisplatin-induced inter-strand crosslink lesion at the +2 position.
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DNDPSDYVEqdDI |
| Chain | Residue | Details |
| C | ASP136-ILE148 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH |
| Chain | Residue | Details |
| I | TYR112-HIS118 |
| site_id | PS00446 |
| Number of Residues | 41 |
| Details | RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP |
| Chain | Residue | Details |
| C | ASN32-PRO72 |
| site_id | PS00466 |
| Number of Residues | 38 |
| Details | ZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW |
| Chain | Residue | Details |
| I | CYS86-TRP123 |
| site_id | PS01030 |
| Number of Residues | 27 |
| Details | RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCQECNNMLypkedkenrillyaCrnC |
| Chain | Residue | Details |
| I | PHE16-CYS42 |
| site_id | PS01110 |
| Number of Residues | 14 |
| Details | RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE |
| Chain | Residue | Details |
| E | HIS142-GLU155 |
| site_id | PS01111 |
| Number of Residues | 15 |
| Details | RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ |
| Chain | Residue | Details |
| F | THR58-GLN72 |
| site_id | PS01112 |
| Number of Residues | 10 |
| Details | RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG |
| Chain | Residue | Details |
| J | ILE2-GLY11 |
| site_id | PS01154 |
| Number of Residues | 32 |
| Details | RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP |
| Chain | Residue | Details |
| K | ILE35-PRO66 |
| site_id | PS01166 |
| Number of Residues | 13 |
| Details | RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT |
| Chain | Residue | Details |
| B | GLY932-THR944 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI21 |
| Number of Residues | 25 |
| Details | Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 42 |
| Details | Zinc finger: {"description":"TFIIS-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10145","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
