9VI9
Cryo-EM Structure of NPFFR1 in complex with peptide RFRP-3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Neuropeptide FF receptor 1 | polymer | 310 | 35150.6 | 1 | UniProt (Q9GZQ6) Pfam (PF00001) | Homo sapiens (human) | G-protein coupled receptor 147,RFamide-related peptide receptor OT7T022 |
| 2 | B (B) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 349 | 39966.4 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 338 | 37198.7 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 4 | D (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 54 | 5931.9 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (P) | RFRP-3 | polymer | 9 | 1042.2 | 1 | Homo sapiens | ||
| 6 | F (S) | scFv16 | polymer | 248 | 26466.5 | 1 | Homo sapiens |
Sequence modifications
A: 29 - 338 (UniProt: Q9GZQ6)
B: 6 - 354 (UniProt: P63096)
| PDB | External Database | Details |
|---|---|---|
| Trp 132 | Phe 132 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asn 47 | Ser 47 | conflict |
| Ala 203 | Gly 203 | conflict |
| Ser 326 | Ala 326 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 145756.3 | |
| All* | Total formula weight | 145756.3 |
