9VH0
SIRT2-H187A structure in complex with H3K18myr peptide and native NAD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NAD-dependent protein deacetylase sirtuin-2 | polymer | 302 | 34193.5 | 2 | UniProt (Q8IXJ6) Pfam (PF02146) | Homo sapiens (human) | NAD-dependent protein defatty-acylase sirtuin-2,Regulatory protein SIR2 homolog 2,SIR2-like protein 2 |
| 2 | C, D (C, D) | Histone H3.1 | polymer | 6 | 713.9 | 2 | UniProt (P68431) | Homo sapiens | Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l |
| 3 | E, G (A, B) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 2 | Chemie (NAD) | |||
| 4 | F, H (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | I, J (C, D) | MYRISTIC ACID | non-polymer | 228.4 | 2 | Chemie (MYR) | |||
| 6 | K, L (A, B) | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
A, B: 54 - 355 (UniProt: Q8IXJ6)
| PDB | External Database | Details |
|---|---|---|
| Ala 187 | His 187 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 69814.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1914.4 | |
| All* | Total formula weight | 71729.1 |
