9V6J
Structure-Guided Design of Picomolar-level Macrocyclic TRPC5 Channel Inhibitors with Antidepressant Activity
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Short transient receptor potential channel 5 | polymer | 975 | 111591.1 | 8 | UniProt (Q9QX29) Pfam (PF12796) Pfam (PF00023) Pfam (PF08344) Pfam (PF00520) | Mus musculus (house mouse) | TrpC5,Capacitative calcium entry channel 2,CCE2,Transient receptor protein 5,TRP-5,mTRP5,Trp-related protein 5 |
| 2 | AA, DA, I, L, O... (G, H, A, B, C...) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | BA, EA, J, M, P... (G, H, A, B, C...) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 4 | CA, FA, K, N, Q... (G, H, A, B, C...) | (E)-1-(4-chlorobenzyl)-3-fluoro-1-(3-hydroxypropyl)-1,1,1,1-tetrahydro-1H-2,4-dioxa-1(8,3)-purina-3(1,3)-benzenacyclodecaphane-1,1-dione | non-polymer | 543.0 | 8 | Chemie (A1EH7) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 892728.6 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 5187.8 | |
| All* | Total formula weight | 897916.4 |
