9V6J
Structure-Guided Design of Picomolar-level Macrocyclic TRPC5 Channel Inhibitors with Antidepressant Activity
This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
| site_id | PS00962 |
| Number of Residues | 12 |
| Details | RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. LiSLFTANSHLG |
| Chain | Residue | Details |
| A | LEU493-GLY504 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 272 |
| Details | Intramembrane: {"description":"Discontinuously helical; Name=Pre-S1","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 232 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 160 |
| Details | Transmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 856 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 112 |
| Details | Transmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 160 |
| Details | Transmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 160 |
| Details | Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 176 |
| Details | Transmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 160 |
| Details | Transmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 240 |
| Details | Repeat: {"description":"ANK 1","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 224 |
| Details | Repeat: {"description":"ANK 2","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 232 |
| Details | Repeat: {"description":"ANK 4","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 64 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 8 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
