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9UHC

FGFR1 kinase domain with a covalent inhibitor 9p

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Fibroblast growth factor receptor 1polymer31035264.52UniProt (P11362)
Pfam (PF07714)
Homo sapiens (human)FGFR-1,Basic fibroblast growth factor receptor 1,BFGFR,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr
2C, I
(A, B)
~{N}-[1-methyl-3-[2-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]-5~{H}-pyrrolo[2,3-b]pyrazin-7-yl]indol-6-yl]propanamidenon-polymer498.62Chemie (A1EPE)
3D, E, F, G, H...
(A, B)
SULFATE IONnon-polymer96.16Chemie (SO4)
4K, L
(A, B)
waterwater18.0446Chemie (HOH)
Sequence modifications
A, B: 458 - 765 (UniProt: P11362)
PDBExternal DatabaseDetails
Gly 456-expression tag
Pro 457-expression tag
Ser 584Cys 584conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight70529.0
Non-Polymers*Number of molecules8
Total formula weight1573.5
All*Total formula weight72102.6
*Water molecules are not included.

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PDB entries from 2025-10-01

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