9U5F

cryo-EM structure of l-SPD binding to D2R

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, B)	Isoform 2 of D(2) dopamine receptor,Soluble cytochrome b562	polymer	428	49144.1	2	UniProt (P14416) UniProt (P0ABE7)	Homo sapiens (human)	Dopamine D2 receptor,Cytochrome b-562
2	B (L)	light chain of Fab3089	polymer	215	23884.3	1		Homo sapiens
3	C (H)	heavy chain of Fab3089	polymer	220	23443.1	1		Homo sapiens
4	E, F, H, I (A, B)	CHOLESTEROL	non-polymer		386.7	4	Chemie (CLR) PubChem (5997)
5	G, J (A, B)	(13~{a}~{S})-3,9-dimethoxy-6,8,13,13~{a}-tetrahydro-5~{H}-isoquinolino[2,1-b]isoquinoline-2,10-diol	non-polymer		327.4	2	Chemie (A1EN9)

Sequence modifications

A, B: 1 - 245 (UniProt: P14416)

PDB	External Database	Details
Lys 121	Ser 121	conflict
Trp 123	Leu 123	conflict

A, B: 251 - 355 (UniProt: P0ABE7)

PDB	External Database	Details
Trp 257	Met 29	conflict
Ile 352	His 124	conflict
Leu 356	-	linker
Glu 357	-	linker
Arg 358	-	linker
Ala 359	-	linker
Arg 360	-	linker
Ser 361	-	linker
Thr 362	-	linker

A, B: 363 - 443 (UniProt: P14416)

PDB	External Database	Details
Ala 246	-	linker
Arg 247	-	linker
Arg 248	-	linker
Gln 249	-	linker
Leu 250	-	linker
His 444	-	expression tag
His 445	-	expression tag
His 446	-	expression tag
His 447	-	expression tag
His 448	-	expression tag
His 449	-	expression tag
His 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	145615.6
Non-Polymers*	Number of molecules	6
	Total formula weight	2201.4
All*	Total formula weight	147816.9

*Water molecules are not included.