9U4M
Focused refinement of 19S in the substrate-engaged human 26S proteasome bound to midnolin with RPT6 at top of spiral staircase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (Y) | 26S proteasome non-ATPase regulatory subunit 6 | polymer | 389 | 45592.3 | 1 | UniProt (Q15008) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN7,26S proteasome regulatory subunit S10,Breast cancer-associated protein SGA-113M,Phosphonoformate immuno-associated protein 4,Proteasome regulatory particle subunit p44S10,p42A |
| 2 | B (a) | 26S proteasome non-ATPase regulatory subunit 13 | polymer | 376 | 42995.4 | 1 | UniProt (Q9UNM6) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN9,26S proteasome regulatory subunit S11,26S proteasome regulatory subunit p40.5 |
| 3 | C (v) | substrate peptide | polymer | 8 | 586.6 | 1 | Homo sapiens (human) | ||
| 4 | D (B) | 26S proteasome regulatory subunit 4 | polymer | 440 | 49260.5 | 1 | UniProt (P62191) | Homo sapiens (human) | P26s4,26S proteasome AAA-ATPase subunit RPT2,Proteasome 26S subunit ATPase 1 |
| 5 | E (c) | 26S proteasome non-ATPase regulatory subunit 14 | polymer | 309 | 34488.8 | 1 | UniProt (O00487) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN11,26S proteasome-associated PAD1 homolog 1 |
| 6 | F (Z) | 26S proteasome non-ATPase regulatory subunit 7 | polymer | 324 | 37086.4 | 1 | UniProt (P51665) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN8,26S proteasome regulatory subunit S12,Mov34 protein homolog,Proteasome subunit p40 |
| 7 | G (e) | 26S proteasome complex subunit SEM1 | polymer | 70 | 8284.6 | 1 | UniProt (P60896) | Homo sapiens (human) | 26S proteasome complex subunit DSS1,Deleted in split hand/split foot protein 1,Split hand/foot deleted protein 1,Split hand/foot malformation type 1 protein |
| 8 | H (U) | 26S proteasome non-ATPase regulatory subunit 1 | polymer | 953 | 105958.2 | 1 | UniProt (Q99460) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN2,26S proteasome regulatory subunit S1,26S proteasome subunit p112 |
| 9 | I (W) | 26S proteasome non-ATPase regulatory subunit 12 | polymer | 456 | 52979.4 | 1 | UniProt (O00232) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN5,26S proteasome regulatory subunit p55 |
| 10 | J (A) | 26S proteasome regulatory subunit 7 | polymer | 433 | 48700.8 | 1 | UniProt (P35998) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT1,Proteasome 26S subunit ATPase 2 |
| 11 | K (C) | 26S proteasome regulatory subunit 8 | polymer | 398 | 44852.1 | 1 | UniProt (P62195) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT6,Proteasome 26S subunit ATPase 5,Proteasome subunit p45,Thyroid hormone receptor-interacting protein 1,TRIP1,p45/SUG |
| 12 | L (D) | 26S proteasome regulatory subunit 6B | polymer | 418 | 47426.1 | 1 | UniProt (P43686) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT3,MB67-interacting protein,MIP224,Proteasome 26S subunit ATPase 4,Tat-binding protein 7,TBP-7 |
| 13 | M (E) | Proteasome 26S subunit, ATPase 6 | polymer | 403 | 45867.0 | 1 | UniProt (A0A087X2I1) | Homo sapiens (human) | 26S proteasome regulatory subunit 10B |
| 14 | N (F) | 26S proteasome regulatory subunit 6A | polymer | 439 | 49266.5 | 1 | UniProt (P17980) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT5,Proteasome 26S subunit ATPase 3,Proteasome subunit P50,Tat-binding protein 1,TBP-1 |
| 15 | O (X) | 26S proteasome non-ATPase regulatory subunit 11 | polymer | 422 | 47526.7 | 1 | UniProt (O00231) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN6,26S proteasome regulatory subunit S9,26S proteasome regulatory subunit p44.5 |
| 16 | P (V) | 26S proteasome non-ATPase regulatory subunit 3 | polymer | 533 | 60935.3 | 1 | UniProt (O43242) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN3,26S proteasome regulatory subunit S3,Proteasome subunit p58 |
| 17 | Q (d) | 26S proteasome non-ATPase regulatory subunit 8 | polymer | 349 | 39536.7 | 1 | UniProt (P48556) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN12,26S proteasome regulatory subunit S14,p31 |
| 18 | R (b) | 26S proteasome non-ATPase regulatory subunit 4 | polymer | 377 | 40781.6 | 1 | UniProt (P55036) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN10,26S proteasome regulatory subunit S5A,Antisecretory factor 1,AF,ASF,Multiubiquitin chain-binding protein |
| 19 | S, U, Z (B, A, F) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 3 | Chemie (ADP) | |||
| 20 | T (c) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 21 | V, X, Y (C, D, E) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 3 | Chemie (ATP) | |||
| 22 | W (C) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 802125.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2892.9 | |
| All* | Total formula weight | 805017.9 |
