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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9TAY

Structure of the human inner kinetochore CCAN bound to a di-CENP-A nucleosome

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(H)		Centromere protein Hpolymer24728520.91UniProt (Q9H3R5)Homo sapiens (human)CENP-H,Interphase centromere complex protein 35
2B
(I)		Centromere protein Ipolymer76287615.01UniProt (Q92674)Homo sapiens (human)CENP-I,FSH primary response protein 1,Follicle-stimulating hormone primary response protein,Interphase centromere complex protein 19,Leucine-rich primary response protein 1
3C
(K)		Centromere protein Kpolymer26931696.11UniProt (Q9BS16)Homo sapiens (human)CENP-K,Interphase centromere complex protein 37,Protein AF-5alpha,p33
4D
(L)		Centromere protein Lpolymer34839364.01UniProt (Q8N0S6)Homo sapiens (human)CENP-L,Interphase centromere complex protein 33
5E
(M)		Centromere protein Mpolymer18019761.91UniProt (Q9NSP4)Homo sapiens (human)CENP-M,Interphase centromere complex protein 39,Proliferation-associated nuclear element protein 1
6F
(N)		Centromere protein Npolymer34740541.61UniProt (Q96H22)Homo sapiens (human)CENP-N,Interphase centromere complex protein 32
7G
(O)		Centromere protein Opolymer30033830.61UniProt (Q9BU64)Homo sapiens (human)CENP-O,Interphase centromere complex protein 36
8H
(Q)		Centromere protein Qpolymer21524634.51UniProt (Q7L2Z9)Homo sapiens (human)CENP-Q
9I
(U)		Centromere protein Upolymer21124484.91UniProt (Q71F23)Homo sapiens (human)CENP-U,Centromere protein of 50 kDa,CENP-50,Interphase centromere complex protein 24,KSHV latent nuclear antigen-interacting protein 1,MLF1-interacting protein,Polo-box-interacting protein 1
10J
(P)		Centromere protein Ppolymer28833210.91UniProt (Q6IPU0)Homo sapiens (human)CENP-P
11K
(R)		Centromere protein Rpolymer17720228.31UniProt (Q13352)Homo sapiens (human)CENP-R,Beta-3-endonexin,Integrin beta-3-binding protein,Nuclear receptor-interacting factor 3
12L
(T)		Methylated-DNA--protein-cysteine methyltransferase,Centromere protein Tpolymer77784067.71UniProt (P16455)
UniProt (Q96BT3)		Homo sapiens (human)6-O-methylguanine-DNA methyltransferase,MGMT,O-6-methylguanine-DNA-alkyltransferase,CENP-T,Interphase centromere complex protein 22
13M
(W)		Centromere protein Wpolymer8810087.21UniProt (Q5EE01)Homo sapiens (human)CENP-W,Cancer-up-regulated gene 2 protein
14N
(S)		Centromere protein Spolymer13815917.91UniProt (Q8N2Z9)Homo sapiens (human)CENP-S,Apoptosis-inducing TAF9-like domain-containing protein 1,FANCM-associated histone fold protein 1,FANCM-interacting histone fold protein 1,Fanconi anemia-associated polypeptide of 16 kDa
15O
(X)		Centromere protein Xpolymer818972.41UniProt (A8MT69)Homo sapiens (human)CENP-X,FANCM-associated histone fold protein 2,FANCM-interacting histone fold protein 2,Fanconi anemia-associated polypeptide of 10 kDa,Retinoic acid-inducible gene D9 protein homolog,Stimulated by retinoic acid gene 13 protein homolog
16BA, FA, P, T
(A, E, c, g)		Histone H3-like centromeric protein Apolymer14016023.64UniProt (P49450)Homo sapiens (human)Centromere autoantigen A,Centromere protein A,CENP-A
17CA, GA, Q, U
(B, F, d, h)		Histone H4polymer10311394.44UniProt (P62805)Homo sapiens (human)
18DA, HA, R, V
(C, G, e, i)		Histone H2A type 1-Cpolymer15316666.34UniProt (Q93077)Homo sapiens (human)H2A-clustered histone 6,Histone H2A/l
19EA, IA, S, W
(D, J, f, j)		Histone H2B type 1-C/E/F/G/Ipolymer12613937.24UniProt (P62807)Homo sapiens (human)Histone H2B.1 A,Histone H2B.a,H2B/a,Histone H2B.g,H2B/g,Histone H2B.h,H2B/h,Histone H2B.k,H2B/k,Histone H2B.l,H2B/l
20X
(V)		DNA (318-MER)polymer32499810.61Homo sapiens
21Y
(Y)		DNA (318-MER)polymer324100290.81Homo sapiens
22AA, JA, KA, Z
(Z, a, m, n)		scFvpolymer26629161.34Mus musculus
Sequence modifications
I: 1 - 756 (UniProt: Q92674)
PDBExternal DatabaseDetails
Glu 757-expression tag
Asn 758-expression tag
Leu 759-expression tag
Tyr 760-expression tag
Phe 761-expression tag
Gln 762-expression tag
L: 1 - 344 (UniProt: Q8N0S6)
PDBExternal DatabaseDetails
Gly -3-expression tag
Pro -2-expression tag
Leu -1-expression tag
Gly 0-expression tag
N: 1 - 339 (UniProt: Q96H22)
PDBExternal DatabaseDetails
Lys 288Glu 288conflict
Ser 340-expression tag
Asp 341-expression tag
Leu 342-expression tag
Glu 343-expression tag
Val 344-expression tag
Leu 345-expression tag
Phe 346-expression tag
Gln 347-expression tag
O: 89 - 300 (UniProt: Q9BU64)
PDBExternal DatabaseDetails
Met 1-initiating methionine
Glu 2-expression tag
Gln 3-expression tag
Ala 4-expression tag
Asn 5-expression tag
Pro 6-expression tag
Leu 7-expression tag
Arg 8-expression tag
Pro 9-expression tag
Asp 10-expression tag
Gly 11-expression tag
Glu 12-expression tag
Ser 13-expression tag
Lys 14-expression tag
Gly 15-expression tag
Gly 16-expression tag
Val 17-expression tag
Leu 18-expression tag
Ala 19-expression tag
His 20-expression tag
Leu 21-expression tag
Glu 22-expression tag
Arg 23-expression tag
Leu 24-expression tag
Glu 25-expression tag
Thr 26-expression tag
Gln 27-expression tag
Val 28-expression tag
Ser 29-expression tag
Arg 30-expression tag
Ser 31-expression tag
Arg 32-expression tag
Lys 33-expression tag
Gln 34-expression tag
Ser 35-expression tag
Glu 36-expression tag
Glu 37-expression tag
Leu 38-expression tag
Gln 39-expression tag
Ser 40-expression tag
Val 41-expression tag
Gln 42-expression tag
Ala 43-expression tag
Gln 44-expression tag
Glu 45-expression tag
Gly 46-expression tag
Ala 47-expression tag
Leu 48-expression tag
Gly 49-expression tag
Thr 50-expression tag
Lys 51-expression tag
Ile 52-expression tag
His 53-expression tag
Lys 54-expression tag
Leu 55-expression tag
Arg 56-expression tag
Arg 57-expression tag
Leu 58-expression tag
Arg 59-expression tag
Asp 60-expression tag
Glu 61-expression tag
Leu 62-expression tag
Arg 63-expression tag
Ala 64-expression tag
Val 65-expression tag
Val 66-expression tag
Arg 67-expression tag
His 68-expression tag
Arg 69-expression tag
Arg 70-expression tag
Ala 71-expression tag
Ser 72-expression tag
Val 73-expression tag
Lys 74-expression tag
Ala 75-expression tag
Cys 76-expression tag
Ile 77-expression tag
Ala 78-expression tag
Asn 79-expression tag
Val 80-expression tag
Glu 81-expression tag
Pro 82-expression tag
Asn 83-expression tag
Gln 84-expression tag
Thr 85-expression tag
Val 86-expression tag
Glu 87-expression tag
Ile 88-expression tag
Q: 55 - 268 (UniProt: Q7L2Z9)
PDBExternal DatabaseDetails
Met 54-initiating methionine
U: 243 - 418 (UniProt: Q71F23)
PDBExternal DatabaseDetails
Glu 419-expression tag
Asn 420-expression tag
Leu 421-expression tag
Tyr 422-expression tag
Phe 423-expression tag
Gln 424-expression tag
Ser 425-expression tag
Trp 426-expression tag
Ser 427-expression tag
His 428-expression tag
Pro 429-expression tag
Gln 430-expression tag
Phe 431-expression tag
Glu 432-expression tag
Lys 433-expression tag
Gly 434-expression tag
Gly 435-expression tag
Gly 436-expression tag
Ser 437-expression tag
Gly 438-expression tag
Gly 439-expression tag
Gly 440-expression tag
Ser 441-expression tag
Gly 442-expression tag
Gly 443-expression tag
Gly 444-expression tag
Ser 445-expression tag
Trp 446-expression tag
Ser 447-expression tag
His 448-expression tag
Pro 449-expression tag
Gln 450-expression tag
Phe 451-expression tag
Glu 452-expression tag
Lys 453-expression tag
T: -191 - -10 (UniProt: P16455)
PDBExternal DatabaseDetails
Met -215-initiating methionine
Ser -214-expression tag
Tyr -213-expression tag
Tyr -212-expression tag
His -211-expression tag
His -210-expression tag
His -209-expression tag
His -208-expression tag
His -207-expression tag
His -206-expression tag
Asp -205-expression tag
Tyr -204-expression tag
Asp -203-expression tag
Ile -202-expression tag
Pro -201-expression tag
Thr -200-expression tag
Thr -199-expression tag
Glu -198-expression tag
Asn -197-expression tag
Leu -196-expression tag
Tyr -195-expression tag
Phe -194-expression tag
Gln -193-expression tag
Gly -192-expression tag
Arg -162Glu 30conflict
Ile -160Lys 32conflict
Phe -159Leu 33conflict
Ala -130Cys 62conflict
Ser -77Gln 115conflict
His -76Gln 116conflict
Ala -67Lys 125conflict
Thr -65Ala 127conflict
Ala -64Arg 128conflict
Lys -61Gly 131conflict
Thr -60Gly 132conflict
Leu -58Met 134conflict
Ser -57Arg 135conflict
Gln -42Cys 150conflict
Gly -41Ser 151conflict
Asp -40Ser 152conflict
Leu -39Gly 153conflict
Asp -38Ala 154conflict
Gly -35Asn 157conflict
Glu -33Ser 159conflict
Ser -9-linker
Asp -8-linker
Leu -7-linker
Glu -6-linker
Val -5-linker
Leu -4-linker
Phe -3-linker
Gln -2-linker
Gly -1-linker
Pro 0-linker
T: 1 - 561 (UniProt: Q96BT3)
C, G, e, i: 0 - 129 (UniProt: Q93077)
PDBExternal DatabaseDetails
Met -23-initiating methionine
Gly -22-expression tag
Ser -21-expression tag
Ser -20-expression tag
His -19-expression tag
His -18-expression tag
His -17-expression tag
His -16-expression tag
His -15-expression tag
His -14-expression tag
Ser -13-expression tag
Pro -12-expression tag
Gly -11-expression tag
Leu -10-expression tag
Glu -9-expression tag
Val -8-expression tag
Leu -7-expression tag
Phe -6-expression tag
Gln -5-expression tag
Gly -4-expression tag
Pro -3-expression tag
Arg -2-expression tag
Gly -1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains37
Total formula weight1051767.4
All*Total formula weight1051767.4
*Water molecules are not included.

253795

PDB entries from 2026-05-20

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