9T9W
Crystal structure of beta-TrCP bound by diphosphorylated I-kappa-B-alpha degron peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | F-box/WD repeat-containing protein 1A | polymer | 365 | 41829.7 | 1 | UniProt (Q9Y297) Pfam (PF00400) | Homo sapiens (human) | E3RSIkappaB,Epididymis tissue protein Li 2a,F-box and WD repeats protein beta-TrCP,pIkappaBalpha-E3 receptor subunit |
| 2 | B (C) | NF-kappa-B inhibitor alpha | polymer | 12 | 1538.4 | 1 | UniProt (P25963) | Homo sapiens (human) | I-kappa-B-alpha,IkB-alpha,IkappaBalpha,Major histocompatibility complex enhancer-binding protein MAD3 |
| 3 | C, D, E, F, G... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 4 | I, J (A, C) | water | water | 18.0 | 338 | Chemie (HOH) |
Sequence modifications
A: 186 - 548 (UniProt: Q9Y297)
| PDB | External Database | Details |
|---|---|---|
| Gly 184 | - | expression tag |
| Ser 185 | - | expression tag |
| Glu 188 | Leu 224 | engineered mutation |
| Glu 192 | Leu 228 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43368.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 372.4 | |
| All* | Total formula weight | 43740.5 |
