9T5S

Crystal structure of human PPARalpha in complex with co-activator PGC-1 alpha peptide and bempedoic acid

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Peroxisome proliferator-activated receptor alpha	polymer	290	32745.1	2	UniProt (Q07869) Pfam (PF00104)	Homo sapiens (human)	PPAR-alpha,Nuclear receptor subfamily 1 group C member 1
2	B, D (B, D)	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	polymer	19	2067.4	2	UniProt (Q9UBK2)	Homo sapiens	PGC-1-alpha,PPAR-gamma coactivator 1-alpha,PPARGC-1-alpha,Ligand effect modulator 6
3	E, F (A, C)	Bempedoic acid	non-polymer		344.5	2	Chemie (A1JTY)
4	G, H, I, J (A, B, C, D)	water	water		18.0	340	Chemie (HOH)

Sequence modifications

A, C: 200 - 468 (UniProt: Q07869)

PDB	External Database	Details
Met 179	-	initiating methionine
Gly 180	-	expression tag
Ser 181	-	expression tag
Ser 182	-	expression tag
His 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag
His 186	-	expression tag
His 187	-	expression tag
His 188	-	expression tag
Ser 189	-	expression tag
Ser 190	-	expression tag
Gly 191	-	expression tag
Leu 192	-	expression tag
Val 193	-	expression tag
Pro 194	-	expression tag
Arg 195	-	expression tag
Gly 196	-	expression tag
Ser 197	-	expression tag
His 198	-	expression tag
Met 199	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	69625.0
Non-Polymers*	Number of molecules	2
	Total formula weight	689.0
All*	Total formula weight	70314.0

*Water molecules are not included.