9T07
HUMAN PI3KDELTA IN COMPLEX WITH Roginolisib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | polymer | 1044 | 119633.0 | 1 | UniProt (O00329) Pfam (PF02192) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | Homo sapiens (human) | PI3-kinase subunit delta,PI3K-delta,PI3Kdelta,PtdIns-3-kinase subunit delta,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta,PtdIns-3-kinase subunit p110-delta,p110delta |
| 2 | B (B) | Phosphatidylinositol 3-kinase regulatory subunit alpha | polymer | 169 | 20879.6 | 1 | UniProt (P23727) Pfam (PF16454) | Bos taurus (domestic cattle) | PI3-kinase regulatory subunit alpha,PI3K regulatory subunit alpha,PtdIns-3-kinase regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PI3-kinase subunit p85-alpha,PtdIns-3-kinase regulatory subunit p85-alpha |
| 3 | C (A) | [6-fluoranyl-1-[4-(morpholin-4-ylmethyl)phenyl]-5,5-bis(oxidanylidene)-4H-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-yl-methanone | non-polymer | 526.6 | 1 | Chemie (QGU) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 140512.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 526.6 | |
| All* | Total formula weight | 141039.2 |
